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Abstract #0161

Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7 Tesla: Apparent increase in frontal cortex water T2 in aged patients with progressive multiple sclerosis stabilizes in biexponential model constrained by tissue and CSF partial volumes

Kelley M. Swanberg1,2, Hetty Prinsen1, Abhinav V. Kurada2, Katherine DeStefano3, Mary Bailey4, David Pitt3, Robert K. Fulbright1, and Christoph Juchem1,2,3,5

1Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States, 2Department of Biomedical Engineering, Columbia University School of Engineering and Applied Science, New York, NY, United States, 3Department of Neurology, Yale University School of Medicine, New Haven, CT, United States, 4Mandell Multiple Sclerosis Center, Saint Francis Hospital, Hartford, CT, United States, 5Department of Radiology, Columbia University Medical Center, New York, NY, United States

Water is a common internal reference for metabolite quantification by 1H-MRS. We investigate potential influences on water-referenced metabolite quantification by differences in frontal cortex water T2 in individuals with relapsing-remitting, progressive, and no multiple sclerosis. Water T2 differed in monoexponential models, exhibiting highest values in progressive multiple sclerosis only when analyses were not age-controlled. Groupwise T2 did not differ in biexponential models constrained by tissue and CSF partial volumes, suggesting that monoexponential T2 differences reflected disparate proportions of water in tissue and CSF rather than differential behavior within them. Our results suggest stability of water T2 within frontal cortex tissue and CSF with multiple sclerosis and emphasize the superiority of metabolite quantification with group-specific T2 values when voxel composition may differ.

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