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Abstract #0165

Enhancing In Vivo Hyperpolarized 13C Chemical Shift Imaging by an Iterative Reconstruction

Gil Farkash1, Stefan Markovic 1, and Lucio Frydman1

1Chemical & Biological Physics, Weizmann Institue, Rehovot, Israel

Hyperpolarized 13C magnetic resonance spectroscopic imaging (MRSI) is a powerful metabolic technique, but it’s challenged by a rapid and irreversible decay of the signal that usually compromises its achievable spatial resolution. In this work we explore a way to improve this by utilizing a priori anatomical information derived from 1H MRI. Enhanced HP-MRSI implementations based on Spectroscopy with Linear Algebraic Modeling (SLAM) were thus assayed, to enhance HP-MRSI’s spatial resolution without compromising SNR. 13C experiments were performed in-vivo and pyruvate/lactate images reconstructed for physiological compartments by SLAM; we compare these results to those arising by traditional Fourier analyses.

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