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Abstract #0179

Cerebral Metabolic Rate of Oxygen (CMRO2) mapping by a joint model of quantitative susceptibility mapping (QSM)-based method and quantitative BOLD (qBOLD)

Junghun Cho1, Youngwook Kee2, Pascal Spincemaille2, Thanh Nguyen2, Jingwei Zhang1, Ajay Gupta2, Shun Zhang2,3, and Yi Wang1,2

1Biomedical Engineering, Cornell University, Ithaca, NY, United States, 2Radiology, Weill Cornell Medical College, New York, NY, United States, 3Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

In this work, we propose a gradient echo (GRE) based measurement of oxygen extraction fraction (OEF) based on a simultaneous modeling of the magnitude (using quantitative BOLD corrected for non-blood tissue susceptibility) and phase (based on QSM), without additional vascular challenges and empirical assumptions. Compared to methods based on QSM only and on qBOLD only, the proposed model provided better CMRO2 contrast between gray and white matter, and more uniform OEF in healthy subjects.

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