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Abstract #0181

Identify the neurovascular coupling efficacy of long-term depolarization or seizer-like events in the hippocampus with optogenetic single-vessel fMRI

Xuming Chen1,2,3, Filip Sobczak1,4, Yi Chen1,4, and Xin Yu1

1High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2University of Tuebingen, Tuebingen, Germany, 3Neurology, Renmin Hospital of Wuhan Universit, Wuhan University, Wuhan, China, 4Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany

Optogenetic activation can elicit seizure-like events in the hippocampus of anesthetized rats. However, it remains unclear how the hemodynamic signaling responds to the seizure-like events or long-term depolarization in hippocampus. Here, we applied the multi-model fMRI platform to acquire concurrent single-vessel fMRI and calcium signal upon optogenetic stimulation in the hippocampus. The neurovascular coupling coefficient was significantly lower for the long-term depolarization/seizure-like calcium event than that of normally evoked events. The reduced neurovascular coupling efficacy during seizure-like events indicates the lack of sufficient blood supply under high-energy demand of long-term depolarization, and eventually causes tissue damage.

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