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Abstract #0187

Direct Imaging of Diamagnetic Susceptibility of Beta Amyloid Aggregates in Transgenic Mouse Models of Alzheimer’s Disease using Quantitative Susceptibility Mapping MRI

Nan-Jie Gong1,2, Russell Dibb2, and Chunlei Liu1,2

1University of California Berkeley, Berkeley, CA, United States, 2Duke University School of Medicine, Durham, NC, United States

We demonstrated in a phantom that beta amyloid is diamagnetic and can generate strong contrast on susceptibility maps. Based on this, it is further shown both in vivo and ex vivo that magnetic susceptibility mapping could be used to monitor accumulation of amyloid plaques in AD mouse models. Most importantly, the diamagnetic susceptibility map and paramagnetic susceptibility map provided histology-like image contrast for identifying deposition of beta amyloid plaques and iron.

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