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Abstract #0199

T2 Texture Analysis Reveals Potential Cartilage-preserving Effect in Presence of Heterozygous WNT1 Mutation in Human

Sami Lehtovirta1,2, Riikka E Mäkitie3, Victor Casula1,2, Marianne Haapea1, Jaakko Niinimäki1,2, Tuukka Niinimäki4, Arttu Peuna2, Eveliina Lammentausta2, Outi Mäkitie3,5,6, and Miika T Nieminen1,2

1Research Unit of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, 2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland, 3Folkhälsan Institute of Genetics and University of Helsinki, Helsinki, Finland, 4Department of Orthopedics, Oulu University Hospital, Oulu, Finland, 5Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, 6Center for Molecular Medicine, Karolinska Institutet, and Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden

Quantitative MRI (qMRI) assessment of tibiofemoral articular cartilage was performed in 13 WNT1 mutation-positive (MP) subjects and 13 mutation-negative (MN) controls. Cartilage thickness, T2 and T1r relaxation times, and texture features contrast, homogeneity and dissimilarity of T2 maps were determined in six regions of interests. Texture features demonstrated an opposing trend with age between the two groups in medial tibiofemoral cartilage, suggesting a possible age-related cartilage preservation in MP subjects. Similar differences were not observed in the other qMRI parameters, suggesting that texture analysis is a more sensitive and accurate tool for quantitative cartilage assessment than mere mean relaxation time measurements.

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