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Abstract #0202

Isotropic 3D T2 mapping of knee cartilage with a novel water excitation technique

Roberto Colotti1, Jessica A.M. Bastiaansen1, Patrick Omoumi1, and Ruud B. van Heeswijk1,2

1Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

The goal of this study was to develop an isotropic 3D lipid-insensitive T2 mapping technique of knee cartilage. Therefore we combined an existing isotropic 3D T2-prepared gradient-echo T2 mapping technique (Iso3DGRE) with the novel lipid-insensitive binomial off-resonant RF excitation (LIBRE) pulse. LIBRE pulse optimization was performed through numerical simulations and verified in phantom experiments, yielding complete fat signal nulling using a LIBRE pulse as short as 1 ms. T2 mapping of knee cartilage performed in five healthy volunteers with LIBRE excitation allowed for improved cartilage delineation and precise T2 values compared with normal excitation.

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