Abstract #0212

Tilted-CAIPI for Highly Accelerated Distortion-Free EPI with Point Spread Function (PSF) Encoding

Zijing Dong¹, Fuyixue Wang^2,3, Timothy G. Reese², Mary Kate Manhard², Berkin Bilgic², Lawrence L. Wald^2,3, Hua Guo¹, and Kawin Setsompop^2,3

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, ²A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

The main challenge in high-resolution EPI is the significant B₀-distortion and T₂*-blurring artifacts. PSF-encoded EPI has been proposed to achieve distortion- and blurring- free imaging at a cost of extremely long acquisition time, not practical for most applications. In this work, we introduce the “tilted-CAIPI” method, which can provide >20x acceleration for PSF-EPI by utilizing the concept of B₀-inhomogeneity encoding and optimized sampling. With the proposed method, PSF-encoded EPI at a 1mm resolution range can be obtained using just 4-8 EPI-shots. PSF-EPI with tilted-CAIPI was demonstrated for efficient acquisition of distortion- and blurring- free T₂-weighted, T₂*-weighted, and diffusion-weighted images.

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