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Abstract #0212

Tilted-CAIPI for Highly Accelerated Distortion-Free EPI with Point Spread Function (PSF) Encoding

Zijing Dong1, Fuyixue Wang2,3, Timothy G. Reese2, Mary Kate Manhard2, Berkin Bilgic2, Lawrence L. Wald2,3, Hua Guo1, and Kawin Setsompop2,3

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

The main challenge in high-resolution EPI is the significant B0-distortion and T2*-blurring artifacts. PSF-encoded EPI has been proposed to achieve distortion- and blurring- free imaging at a cost of extremely long acquisition time, not practical for most applications. In this work, we introduce the “tilted-CAIPI” method, which can provide >20x acceleration for PSF-EPI by utilizing the concept of B0-inhomogeneity encoding and optimized sampling. With the proposed method, PSF-encoded EPI at a 1mm resolution range can be obtained using just 4-8 EPI-shots. PSF-EPI with tilted-CAIPI was demonstrated for efficient acquisition of distortion- and blurring- free T2-weighted, T2*-weighted, and diffusion-weighted images.

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