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Abstract #0232

Sertraline treatment modulates salience connectivity in major depressive disorder

Li-Ming Hsu1, Changwei W. Wu1, Chien-Yuan Lin2, Chi-Yun Liu1, Timothy Lane1, Ching-Po Lin3, Chi-Bin Yeh4, and Hung-Wen Kao4

1Brain and Consciousness Research Center, Taipei Medical University, Taipei, Taiwan, 2GE Healthcare, Taipei, Taiwan, 3National Yang-Ming University, Taipei, Taiwan, 4Department of Radiology, National Defense Medical Center, Taipei, Taiwan

How sertraline alleviates depressive syndrome by modulating the intrinsic connectivity networks (ICNs) remains elusive. Herein, we take a network-based investigation on SN to rationalize the functional and behavior effect of the sertraline treatment using resting-state functional connectivity (rsFC). Our study demonstrated that the sertraline treatment exhibited beneficial modulations on the DNMTL–SN–thalamus pathway for alleviating depressive syndromes in MDD patients.

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