Abstract #0240

MRI texture features as predictors of histopathologic and genomic characteristics of hepatocellular carcinoma.

Stefanie Hectors¹, Sara Lewis^1,2, Cecilia Besa¹, Michael King², Juan Putra³, Stephen Ward³, Takaaki Higashi⁴, Swan Thung³, Yujin Hoshida⁴, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Medicine/Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of this study was to assess the diagnostic value of texture features measured with MRI compared to qualitative imaging traits for the prediction of histopathologic and genomic characteristics of hepatocellular carcinoma (HCC) lesions. Texture features exhibited additional, complementary correlations with histopathology and genomics compared to qualitative imaging traits, including association with microvascular invasion and expression of immunotherapy target CTLA4. These promising results warrant further investigation of texture features as predictors of histopathologic and genomics measurements in HCC.

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