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Abstract #0246

3D Dynamic Hyperpolarized-13C Parallel MRI of Human Brain using SVD Low-Rank Matrix Completion

Hsin-Yu Chen1, Ilwoo Park2, Peng Cao1, Robert A. Bok1, Jeremy W. Gordon1, Peter J. Shin1, James B. Slater1, Mark van Criekinge1, Lucas Carvajal1, Adam Autry1, John Kurhanewicz1, Peder E.Z. Larson1, and Daniel B. Vigneron1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

The goal of this feasibility study was to develop and apply new 3D dynamic hyperpolarized 13C combined parallel imaging + compressed sensing MRI methods for human brain studies. The new framework utilizing multichannel coils and low-rank matrix completion reconstruction provided greatly improved coverage as compared to prior 2D acquisitions. Whole-brain coverage was achieved, while maintaining the image quality in terms of spatial distribution, temporal dynamics and quantitative accuracy of the 13C biomarkers. Animal studies and simulations also showed that the pMRI+CS framework provided improved performance over CS alone, and was able better to recover low-SNR peaks.

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