Abstract #0246

3D Dynamic Hyperpolarized-13C Parallel MRI of Human Brain using SVD Low-Rank Matrix Completion

Hsin-Yu Chen¹, Ilwoo Park², Peng Cao¹, Robert A. Bok¹, Jeremy W. Gordon¹, Peter J. Shin¹, James B. Slater¹, Mark van Criekinge¹, Lucas Carvajal¹, Adam Autry¹, John Kurhanewicz¹, Peder E.Z. Larson¹, and Daniel B. Vigneron¹

¹Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²Department of Radiology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea

The goal of this feasibility study was to develop and apply new 3D dynamic hyperpolarized ¹³C combined parallel imaging + compressed sensing MRI methods for human brain studies. The new framework utilizing multichannel coils and low-rank matrix completion reconstruction provided greatly improved coverage as compared to prior 2D acquisitions. Whole-brain coverage was achieved, while maintaining the image quality in terms of spatial distribution, temporal dynamics and quantitative accuracy of the ¹³C biomarkers. Animal studies and simulations also showed that the pMRI+CS framework provided improved performance over CS alone, and was able better to recover low-SNR peaks.

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