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Abstract #0255

Unconstrained Estimation of Microstructure by the Combination of Single- and Double-planar diffusion encoding

Marco Reisert1, Valerij G. Kiselev1, and Bibek Dhital1

1University Freiburg, Faculty of Medicine, Freiburg, Germany

Modeling of white matter microstructure using standard diffusion MRI protocols is a poor-conditioned problem. With standard measurements there is a global degeneracy: There are two significantly different microstructural parameter sets explaining experimental data equally well. In this work we use an additional planar double diffusion encoding to resolve the degeneracy, and extend a Bayesian estimation framework to a combination of linear and planar diffusion encoding. This enables us to produce reliable estimates without applying any constraints to the microstructural diffusion model.

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