Abstract #0264

Myelin water atlas: a template for myelin distribution in the brain

Hanwen Liu^1,2, Cristina Rubino³, Mike Jarrett^4,5, Emil Ljungberg⁶, Irene Vavasour⁷, Shannon Kolind^1,7,8, Erin Leigh MacMillan^9,10,11, Tony Traboulsee¹², Donna Lang⁷, Alex Rauscher^4,7, David Li⁷, Alex MacKay^1,7, Lara Boyd¹³, John Kramer^2,14, and Cornelia Laule^2,7

¹Physics, University of British Columbia, Vancouver, BC, Canada, ²International Collaboration on Repair Discoveries, Vancouver, BC, Canada, ³Rehabilitation Sciences, University of British Columbia, Vancouver, BC, Canada, ⁴Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁵UBC MRI Research Centre, University of British Columbia, Vancouver, ON, Canada, ⁶IoPPN, King's College London, London, United Kingdom, ⁷Radiology, University of British Columbia, Vancouver, BC, Canada, ⁸Medicine, University of British Columbia, Vancouver, BC, Canada, ⁹MR Clinical Science, Philips Healthcare Canada, Markham, ON, Canada, ¹⁰UBC MRI Research Centre, University of British Columbia, Vancouver, BC, Canada, ¹¹ImageTech Lab, Simon Fraser University, Surrey, BC, Canada, ¹²University of British Columbia, Vancouver, BC, Canada, ¹³Physical Therapy, University of British Columbia, Vancouver, BC, Canada, ¹⁴Kinesiology, University of British Columbia, Vancouver, BC, Canada

In-vivo information about myelin content in the brain is desirable for studying brain diseases and injuries. Normative information is key for determining what is abnormal when assessing neurological conditions that affect myelin. We used myelin water imaging to create a template specific to myelin, the myelin water atlas, for healthy brains. The resulting atlas shows strong agreement with well-known anatomical features that have demonstrated that different brain regions have distinct amounts of myelin. Our work shows one of the potential applications of using the myelin water atlas as a reference to visualize demyelination in the brain of individual subjects.

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