Abstract #0284

Assessment of Myocardial Fibre Architecture in Cardiac Amyloidosis Patients using In-Vivo Cardiac Diffusion Tensor Imaging

Constantin von Deuster¹, Alexander Gotschy^1,2, Robbert J.H. van Gorkum¹, Mareike Gastl^1,2,3, Ella Vintschger¹, Andreas Flammer², Robert Manka^1,2, Christian T. Stoeck¹, and Sebastian Kozerke¹

¹Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ²Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, ³Dept. Cardiology, Pneumology and Angiology, Heinrich Heine University, Düsseldorf, Germany

In-vivo cardiac diffusion tensor imaging (cDTI) allows imaging of alterations in the cardiac fibre architecture in diseased hearts. In this work, changes in the myocardial microstructure in patients with cardiac amyloidosis were assessed using cDTI and T1 mapping. Mean diffusivity and T1_native are significantly increased in the patients and the helical fibre configuration is comparable to healthy controls. There is a trend towards higher/lower MD/FA with increased T1_native, respectively. In agreement with T1 mapping, diffusion results support the presence of myocardial degeneration and emphasize the potential of cDTI as contrast agent free tool for characterizing cardiac involvement in amyloidosis patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.