Meeting Banner
Abstract #0284

Assessment of Myocardial Fibre Architecture in Cardiac Amyloidosis Patients using In-Vivo Cardiac Diffusion Tensor Imaging

Constantin von Deuster1, Alexander Gotschy1,2, Robbert J.H. van Gorkum1, Mareike Gastl1,2,3, Ella Vintschger1, Andreas Flammer2, Robert Manka1,2, Christian T. Stoeck1, and Sebastian Kozerke1

1Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2Department of Cardiology, University Hospital Zurich, Zurich, Switzerland, 3Dept. Cardiology, Pneumology and Angiology, Heinrich Heine University, Düsseldorf, Germany

In-vivo cardiac diffusion tensor imaging (cDTI) allows imaging of alterations in the cardiac fibre architecture in diseased hearts. In this work, changes in the myocardial microstructure in patients with cardiac amyloidosis were assessed using cDTI and T1 mapping. Mean diffusivity and T1native are significantly increased in the patients and the helical fibre configuration is comparable to healthy controls. There is a trend towards higher/lower MD/FA with increased T1native, respectively. In agreement with T1 mapping, diffusion results support the presence of myocardial degeneration and emphasize the potential of cDTI as contrast agent free tool for characterizing cardiac involvement in amyloidosis patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here