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Abstract #0292

Reduction of Peripheral Nerve Stimulation (PNS) using Pre-Excitation Targeting the Potassium System (PRE-TAPS)

Mathias Davids1,2, Bastien Guérin2,3, Martin Schmelz4, Lothar R Schad1, and Lawrence L Wald2,3,5

1Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, 2Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 3Harvard Medical School, Boston, MA, United States, 4Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany, 5Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

PNS has become the main limitation of fast MRI using current gradient hardware. We recently presented a novel pipeline to simulate magnetically induced PNS thresholds in arbitrary coil geometries. Now, we use this framework and detailed modeling of ion dynamics and Action Potential (AP) generation to test a new strategy for PNS reduction. The method (which we call “PRE-TAPS”) pre-saturates the nerve membrane by playing gradient pulses prior to the main imaging gradient. Our model suggests that this simple pulse-sequence modification could effectively increase PNS thresholds by up to 30%.

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