Abstract #0292

Reduction of Peripheral Nerve Stimulation (PNS) using Pre-Excitation Targeting the Potassium System (PRE-TAPS)

Mathias Davids^1,2, Bastien Guérin^2,3, Martin Schmelz⁴, Lothar R Schad¹, and Lawrence L Wald^2,3,5

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Martinos Center for Biomedical Imaging, Dept. of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Department of Anesthesiology Mannheim, Heidelberg University, Mannheim, Germany, ⁵Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, United States

PNS has become the main limitation of fast MRI using current gradient hardware. We recently presented a novel pipeline to simulate magnetically induced PNS thresholds in arbitrary coil geometries. Now, we use this framework and detailed modeling of ion dynamics and Action Potential (AP) generation to test a new strategy for PNS reduction. The method (which we call “PRE-TAPS”) pre-saturates the nerve membrane by playing gradient pulses prior to the main imaging gradient. Our model suggests that this simple pulse-sequence modification could effectively increase PNS thresholds by up to 30%.

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