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Abstract #0318

Evaluation of a wave-MPRAGE sequence for brain morphometery

Ross W. Mair1,2, Jared A. Nielsen1,3,4, and Randy L. Buckner1,2,3,4

1Center for Brain Science, Harvard University, Cambridge, MA, United States, 2AA Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 3Department of Psychology, Harvard University, Cambridge, MA, United States, 4Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, United States

A new readout method for 3D scans, wave-CAIPI, with low g-factor characteristics that enable high degrees of acceleration, can reduce the scan time for a 1.0 mm MPRAGE to under 90 seconds. We have validated the morphometrics from this rapid wave-MPRAGE with those from conventional MPRAGE scans. The wave-MPRAGE sequence produces a lower-SNR image of the brain, but surfaces created from the wave images match those from the conventional scans well. In morphometric data, a bias is seen toward the conventional MPRAGE scans in average cortical thickness and estimated total intra-cranial volume, however values for total brain volume are similar.

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