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Abstract #0327

Intramuscular variability and sex difference in diffusion properties and 3D architecture of human lower leg muscles assessed with ultra-high-field diffusion tensor imaging and tractography

Alexandre Fouré1, Augustin C Ogier1, Christophe Vilmen1, Arnaud Le Troter1, Thorsten Feiweier2, Maxime Guye1,3, Julien Gondin4, Pierre Besson1, and David Bendahan1

1Aix-Marseille Univ, CNRS, CRMBM, Marseille, France, 2Siemens Healthcare, Erlangen, Germany, 3APHM, Hôpital Universitaire Timone, CEMEREM, Marseille, France, 4Institut NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM, CNRS, Villeurbanne, France

Skeletal muscle function impairment can be associated to changes in both muscle volume and structural arrangement of fascicles/fibers within the muscle thereby leading to the reduction of muscle force production. Diffusion properties and 3D structural organization of muscle fibers were quantified from high-resolution diffusion tensor images recorded at ultra-high-field MRI (UHF-7T). These parameters were assessed regarding their intramuscular variability and sensitivity to sex difference. This application of UHF-7T might be of high interest for the assessment of muscular injuries in both athletes and patients with muscular disorders.

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