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Abstract #0342

T2-weighted MRI-derived textural features can help the assessment of peripheral zone prostate cancer aggressiveness: results from multi-center data.

Gabriel Nketiah1, Mattijs Elschot1, Tom W Scheenen2, Marnix C Maas2, Tone F Bathen1,3, and Kirsten M Seln├Žs1,3

1Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway, 2Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, Netherlands, 3St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway

The assessment of prostate cancer aggressiveness is currently based on Gleason grading of histological samples obtained by TRUS-guided biopsies, which can lead to substantial underestimations due to sampling errors. We previously showed that textural features derived from T2-weighted MRI could potentially serve as a non-invasive biomarker for prostate cancer aggressiveness. The aim of this work was to validate these preliminary results in a multi-center study. We found that the combination of intensity and textural features could distinguish between low/intermediate and high-grade with an accuracy of 71%, which was significantly higher than intensity (60%) or textural features (68%) alone.

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