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Abstract #0346

Targeted Biopsy Validation of Peripheral Zone Prostate Cancer Characterization with MR Fingerprinting and Diffusion Mapping

Ananya Panda1, Gregory O'Connor2, Yun Jiang1, Alice Yu3, Shivani Pahwa4, Sara Dastmalchian4, Seunghee Margevicius5, Mark Schluchter5, Robert Abouassaly6, Chaitra Badve1,2,4, Mark Griswold1,2,4, Lee Ponsky2,7, and Vikas Gulani1,2,4

1Radiology, Case Western Reserve University, Cleveland, OH, United States, 2School of Medicine, Case Western Reserve University, Cleveland, OH, United States, 3Radiology, Johns Hopkins University, Baltimore, MD, United States, 4Radiology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States, 5Biostatistics, Case Western Reserve University, Cleveland, OH, United States, 6Urology, Cleveland Clinic, Cleveland, OH, United States, 7Urology, University Hospitals Cleveland Medical Center, Cleveland, OH, United States

Targeted biopsy validation is presented for characterization of peripheral zone (PZ) prostate cancer grades and differentiation of prostate cancer from prostatitis, using a quantitative MR protocol comprising of MRF-relaxometry and standard EPI based ADC mapping. Mean T1, T2 and ADC in prostate cancer were significantly lower than in NPZ. Mean T2 and ADC in low-grade cancer were significantly higher than intermediate and high-grade cancer with similar AUCs (0.80) for both for differentiating grades. Mean T2 and ADC in prostate cancer were significantly lower than prostatitis. T2 was a significant predictor for prostate cancer over prostatitis while ADC was not significant.

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