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Abstract #0368

Unraveling Cardiac and Respiratory Contributions to Brain Tissue Motion using Single Shot 2D DENSE at 7T MRI.

Jacob Jan Sloots1, Ayodeji L. Adams1, Peter R. Luijten1, Geert Jan Biessels2, and Jaco J. M. Zwanenburg1

1Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 2Neurology, University Medical Center Utrecht, Utrecht, Netherlands

The cardiac cycle and respiration both influence CSF dynamics and therefore the displacement of brain tissue. In this work we unravel their contribution to brain tissue displacement using a single shot 2D cine displacement-encoded imaging method employing stimulated echoes (DENSE) for brain motion measurements. Displacement-encoded data sets in the Feet-to-Head direction of seven volunteers were fitted to a linear model. Consistent trends in displacements were observed. The developed DENSE sequence results showed similar sized contributions to brain tissue displacement. Relating these displacements to contributions to the clearance system remains future work.

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