Abstract #0375

Multiscale multimodal imaging of the mouse cerebral vascular architecture.

Rukun Hinz¹, Jan R Detrez², Lore Peeters¹, Caroline Berghmans³, Marleen Verhoye¹, Annemie Van der Linden¹, Winnok H De Vos², and Georgios A Keliris¹

¹Bio-imaging Lab, University of Antwerp, Wilrijk, Belgium, ²Laboratory of Cell Biology and Histology, University of Antwerp, Wilrijk, Belgium, ³Molecular Imaging Center Antwerp, University of Antwerp, Wilrijk, Belgium

We present a multiscale multimodal atlas of the mouse cerebral vasculature co-registered to the Allen Brain atlas space. To this end, we combined MRI anatomical imaging with the macro vasculature detected with TOF-MRA as well as the micro vasculature acquired from 3D microscopic imaging of a cleared mouse brain. To achieve a better homogeneity, we used a double labeling of the vasculature using isolectin to stain the vascular wall combined with an albumin staining of the blood vessel lumen. The atlas provides a reference space across multiple imaging modalities and a link to other functional, anatomical and genetic information.

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