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Abstract #0388

Functional Mapping of Body Part Representations across Layers and Columns in Humans

Laurentius Huber1, Jozien Goense2, Pete Molfese1, Daniel Glen3, Dave Jangraw1, Sriranga Kashyap4, Benedikt A Poser4, Daniel A Handwerker1, and Peter A Bandettini1

1SFIM, NIMH, Bethesda, MD, United States, 2University of Glasgow, Glasgow, United Kingdom, 3NIMH, Bethesda, MD, United States, 4MBIC, Maastricht, Netherlands

In this work, we seek to characterize the mesoscopic circuitry of the sensorimotor system across layers, columns and brain areas. We use a blood volume and BOLD signal sensitive fMRI methodology during task and rest with 0.78 mm resolution. We find ‘columnar’-dependent connectivity, representing the same body parts (e.g. digits) across different sensory and motor areas. In the hand knob, we find ‘columnar’ networks with a finer spatial scale than the regime of individual digit representations. Layer-dependent differences of task-induced and resting-state fMRI are indicative of different input-output-driven activity.

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