Several sub-millimetre-resolution fMRI acquisitions have been developed in recent years, however none taken singularly directly reflects neural activity. We use a calibrated BOLD approach combining BOLD and VASO measurements with respiratory manipulations (CO2 and O2) and a motor task to estimate cortical profiles of changes in O2 metabolism, a parameter more tightly related to neuronal function. Calculated hypercapnic calibration parameters are consistent with previous findings, while physiologically implausible estimates of O2 metabolism changes are found with hyperoxic calibration. A possible reason for this is reported, which questions the validity of conventional models for hyperoxic calibration at this resolution.
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