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Abstract #0397

Hypercapnic and hyperoxic laminar calibrated BOLD: are conventional models adequate?

Alberto Merola1, Maria Guidi1, and Nikolaus Weiskopf 1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Several sub-millimetre-resolution fMRI acquisitions have been developed in recent years, however none taken singularly directly reflects neural activity. We use a calibrated BOLD approach combining BOLD and VASO measurements with respiratory manipulations (CO­2 and O2) and a motor task to estimate cortical profiles of changes in O2 metabolism, a parameter more tightly related to neuronal function. Calculated hypercapnic calibration parameters are consistent with previous findings, while physiologically implausible estimates of O2 metabolism changes are found with hyperoxic calibration. A possible reason for this is reported, which questions the validity of conventional models for hyperoxic calibration at this resolution.

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