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Abstract #0402

OATP1A1 reporter gene-enhanced magnetic resonance imaging of Triple Negative Breast Cancer in animal models at 3 Tesla

Nivin N Nyström1,2, Amanda M Hamilton1, Francisco FM Martinez1, Timothy J Scholl1,2,3, and John A Ronald1,2

1Medical Imaging, Robarts Research Institute, London, ON, Canada, 2Medical Biophysics, University of Western Ontario, London, ON, Canada, 3Ontario Institute for Cancer Research, Toronto, ON, Canada

Preclinical cancer models are invaluable for studying oncogenic pathways and assessing therapies. However, precise detection of small tumours with specificity, sensitivity and high resolution remains challenging. A member of the Organic Anion Transporting Polypeptide 1 (OATP1) family of proteins, called OATP1A1, can take up the clinically-approved, liver-specific paramagnetic agent Gd-EOB-DTPA. Significant increases in spin-lattice relaxation rates were exhibited at 3T by triple negative breast cancer (TNBC) cells engineered to express OATP1A1 and pilot data showed enhancement of OATP1A1-expressing orthotopic TNBC tumours in mice. Our data supports the utility of OATP1A1 for improved MR detection of TNBC tumours in animal models.

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