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Abstract #0415

NaSA-CEST: MR monitoring of brain inflammation using an aspirin metabolite as contrast agent

Xiaolei Song1, Yanrong Chen1,2, Chenwang Jin1,3, Chengyan Chu1, Irina Shats1, Yuguo Li1, Yue Yuan1, Xiaowei He2, Piotr Walzcak1, and Jeff W.M Bulte1

1Johns Hopkins Univeristy, Baltimore, MD, United States, 2Northwest University, Xi'an, Shaanxi, China, 3Xi'an Jiaotong University, Xi'an, Shaanxi, China

Sodium salicylate (NaSA), a nonsteroidal anti-inflammatory drug and the main metabolite of aspirin, can accumulate specifically in inflamed tissue. We investigated the use of NaSA-enhanced CEST MRI for in vivo mapping of brain inflammation, induced by intrastriatal injection of lipopolysaccharide (LPS). Inflamed mice exhibited an increase of ~8% NaSA-CEST signal on the AUC10-30min images, with signals for the ipsilateral striatum significantly higher than those for the mirrored contralateral regions. While for the non-inflamed sham mice, which received saline instead of LPS, no such NaSA-CEST signal could be observed. Our NaSA-CEST approach could possibly lead to the development of inflammation-specific theranostics.

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