Abstract #0420

Functional MRI can distinguish between optimal and non-optimal frequencies in PD-DBS

Radhika Madhavan¹, Suresh Emmanuel Joel¹, Saikat Saha¹, Marisa DiMarziio², Eric Fiveland³, Jeffrey Ashe³, Michael Gillogly⁴, Jennifer Durphy⁴, Julia Prusik^2,4, Pilitsis Julie^2,4, and Ileana Hancu³

¹GE Global Research, Bangalore, India, ²Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY, United States, ³GE Global Research, Niskayuna, NY, United States, ⁴Department of Neurosurgery, Albany Medical Center, Albany, NY, United States

Deep Brain Stimulation is an effective treatment for Parkinson's disease symptoms. Despite its success, the underlying principle and the mechanisms are not yet fully understood. In this study, we recorded concurrent DBS-fMRI to 1) elucidate brain regions activated at the clinically optimal settings and, 2) determine the effect of changes in stimulation frequency on whole-brain activation. Optimal DBS frequencies showed activation in the thalamus and motor cortices. Further, there was a significant difference in activation in the sensorimotor cortices between the optimal and non-optimal frequencies, indicating potential use for fMRI as a tool for optimizing DBS parameters.

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