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Abstract #0420

Functional MRI can distinguish between optimal and non-optimal frequencies in PD-DBS

Radhika Madhavan1, Suresh Emmanuel Joel1, Saikat Saha1, Marisa DiMarziio2, Eric Fiveland3, Jeffrey Ashe3, Michael Gillogly4, Jennifer Durphy4, Julia Prusik2,4, Pilitsis Julie2,4, and Ileana Hancu3

1GE Global Research, Bangalore, India, 2Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY, United States, 3GE Global Research, Niskayuna, NY, United States, 4Department of Neurosurgery, Albany Medical Center, Albany, NY, United States

Deep Brain Stimulation is an effective treatment for Parkinson's disease symptoms. Despite its success, the underlying principle and the mechanisms are not yet fully understood. In this study, we recorded concurrent DBS-fMRI to 1) elucidate brain regions activated at the clinically optimal settings and, 2) determine the effect of changes in stimulation frequency on whole-brain activation. Optimal DBS frequencies showed activation in the thalamus and motor cortices. Further, there was a significant difference in activation in the sensorimotor cortices between the optimal and non-optimal frequencies, indicating potential use for fMRI as a tool for optimizing DBS parameters.

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