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Abstract #0450

Human Glioblastoma Cell Lines Co-oxidize [2,4-13C]betahydroxy-butyrate and [U-13C]-glucose: A 13C NMR Spectroscopic Study

Omkar B. Ijare1, Athena Hoppe1, Cole Holan1, Martyn A Sharpe1, David S Baskin1, and Kumar Pichumani1

1Kenneth R. Peak Center, Department of Neurosurgery, Houston Methodist Research Institute, Houston, TX, United States

Ketogenic diet has been proposed for the adjuvant therapy in the treatment of brain tumors. The rationale behind using ketogenic diet in the cancer treatment is the inability of tumor mitochondria to oxidize KBs. Recent studies on ketone body metabolism using 9L and RG2 cell lines and glioma models suggest that brain tumor mitochondria are capable of oxidizing ketone bodies. The current study was undertaken to determine relative utilization of betahydroxy-butyrate (BHB) and glucose in patient-derived glioblastoma cells. Our findings clearly indicate that human brain tumor cells are fully capable of oxidizing ketone bodies even under normoglycemic conditions.

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