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Abstract #0453

Real time observation of shifts in cerebral metabolism caused by cocaine administration via MRS, DNP, and NMR

Joanna Long1, Daniel Downes2, James Collins2, Marcelo Febo2, and Bimala Lama3

1Box 100245, University of Florida, Gainesville, FL, United States, 2University of Florida, Gainesville, FL, United States, 3University of Colorado, Boulder, CO, United States

The high energy requirements of the brain are sustained by a unique metabolic relationship between astrocytes and neurons. Here, we show how cocaine administration shifts neurometabolism at a fundamental level. Using a novel approach combining dynamic nuclear polarization-enabled metabolic flux measurements with steady state magnetic resonance measures of metabolite pools, we reveal acute cocaine administration disrupts the balance of oxidative and non-oxidative metabolic pathways. These results demonstrate significant metabolic shifts in response to cocaine administration, providing insight into the observed short-term effects of cocaine use.

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