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Abstract #0459

Ultrashort Echo Time Imaging of the Osteochondral Junction in Subjects with Knee Osteoarthritis and Age-matched Healthy Volunteers

James W MacKay1, Josh Kaggie1, Alexandra R Morgan2, Robert L Janiczek2, Scott Reid3, Stephen McDonnell4, Wasim Khan4, Martin Graves1, Fiona J Gilbert1, and Andrew McCaskie4

1Radiology, University of Cambridge, Cambridge, United Kingdom, 2Experimental Medicine Imaging, GlaxoSmithKline, Stevenage, United Kingdom, 3GE Healthcare, Little Chalfont, United Kingdom, 4Trauma & Orthopaedics, University of Cambridge, Cambridge, United Kingdom

We describe in vivo translation of ultrashort TE (UTE) imaging of the osteochondral junction (OCJ) at the knee in 9 subjects with osteoarthritis (OA) and 4 age-matched healthy volunteers. The OCJ plays an important role in onset and progression of OA. Our study demonstrates that UTE imaging of the OCJ is repeatable and demonstrates OCJ defects in OA subjects but not in healthy volunteers. Areas of OCJ damage commonly co-locate to other osteochondral pathology (bone marrow lesions and cartilage defects). UTE imaging of the OCJ may be a helpful tool for assessing OCJ damage in clinical studies of OA.

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