Meeting Banner
Abstract #0462

New Diffusion Tensor and Dixon Imaging Results in Human Skeletal Muscle from the GESTALT Longitudinal Study of Aging

Donnie Cameron1,2, David A. Reiter2,3, Fatemeh Adelnia2, Kenneth W. Fishbein2, Christopher M. Bergeron2, Richard G. Spencer2, and Luigi Ferrucci2

1Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 2National Institute on Aging, National Institutes of Health, Baltimore, MD, United States, 3Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States

This work investigates how aging influences skeletal muscle diffusion tensor imaging (DTI) measures in a healthy cohort with a broad age range. Sixty participants, from 23-87 years old, were recruited and tract-based DTI indices were calculated in their thigh quadriceps muscles. Through piecewise regression, we identified trends in DTI indices and Dixon fat measures with respect to age, including a previously undocumented decline in fractional anisotropy (FA) in older age, particularly in men (r=-0.46, p=0.06). Our results also show statistically significant differences in FA between quadriceps muscles (p<0.001) that may reflect differences in composition and patterns of use.

This abstract and the presentation materials are available to members only; a login is required.

Join Here