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Abstract #0500

Improved reliability for mapping water exchange across blood-brain barrier by diffusion prepared three-dimensional pseudo-continuous arterial spin labeling

Xingfeng Shao1 and Danny J.J. Wang1

1Laboratory of FMRI Technology (LOFT), Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States

A 3D diffusion-prepared gradient and spin echo (GRASE) pseudo-continuous ASL (pCASL) sequence was proposed to improve the reliability for mapping water exchange across the BBB non-invasively. The motion sensitive non-CPMG component signal was eliminated by gradients to spread the diffusion weighted signal across 4π before GRASE readout. Based on test-retest scans (~2 weeks apart) in aged subjects (67±8yrs), excellent reproducibility (ICC=0.87) was achieved for water exchange rate (Kw) measured by the proposed 3D sequence. Whole brain Kw was averaged to be 107.7±19.0 min-1 and 113.0±17.8 min-1 for the proposed 3D and 2D DW-pCASL method, respectively, well matching the literature results.

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