Abstract #0510

Assessing Mild Traumatic Brain Injury (TBI) Induced Optic Neuropathy in Novel Closed-head Injury Mouse Model Using Diffusion Basis Spectrum Imaging (DBSI)

Tsen-Hsuan (Abby) Lin¹, Andrew D Sauerbeck², Terrance T Kummer^2,3, and Sheng-Kwei Song^1,3,4

¹Radiology, Washington University School of Medicine, St Louis, MO, United States, ²Neurology, Washington University School of Medicine, St Louis, MO, United States, ³Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, United States, ⁴Biomedical Engineering, Washington Univerisyt is St. Louis, St Louis, MO, United States

Traumatic brain injury (TBI) is a major cause of death and disability worldwide, and mild TBI (mTBI) is the most common type injury. TBI-induced optic neuropathy (ON) has recently raised attention due to subjective complaints of visual impairment. Currently, non-invasive and longitudinal direct assessment in TBI-induced ON is still limited. In the current study, we applied diffusion basis spectrum imaging (DBSI) to a novel surgery-free and closed-head impact model of TBI called modCHIMERA at 3 days post-injury to study TBI-induced ON with histological validation on our imaging metrics.

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