Abstract #0515

Estimating Liver Water and Fat T1 and T2, and PDFF using Flip Angle Corrected Multi-TR, Multi-TE 1H MRS

Gavin Hamilton¹, Alexandra N Schlein¹, Rohit Loomba², and Claude B Sirlin¹

¹Liver Imaging Group, Department of Radiology, University of California, San Diego, La Jolla, CA, United States, ²NAFLD Research Center, Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA, United States

Multi-TR, multi-TE (MTRTE) ¹H MRS estimates T1 and T2 of fat and water and liver proton density fat fraction (PDFF) in a single breath-hold by assuming a perfect 90° pulse, which is not guaranteed in vivo and may introduce bias. We introduce a flip angle corrected multi-TR, multi-TE (FAC MTRTE) ¹H MRS sequence based on a non-steady state approach and compare the T1, T2, and PDFF given by MTRTE and FAC MTRTE MRS. T1 estimates given by MTRTE MRS and FAC MTRTE MRS were significantly different, due to the MTRTE sequence not being acquired with a perfect 90° flip.

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