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Abstract #0533

On the Sensitivity of Bone Marrow Magnetic Susceptibility and R2* on Trabecular Bone Microstructure

Maximilian N. Diefenbach1, Anh Van2, Jakob Meineke3, Jan S. Kirschke4, Benedikt Schwaiger1, Thomas Baum4, Alexandra Gersing1, and Dimitrios C. Karampinos1

1Diagnostic and Interventional Radiology, Technical Univeristy of Munich, Munich, Germany, 2Institute of Medical Engineering, Technical University of Munich, Munich, Germany, 3Philips Research Laboratory, Hamburg, Germany, 4Department of Diagnostic and Interventional Neuroradiology, Technical University of Munich, Munich, Germany

In numerical simulations and initial in vivo results of multi-parametric mapping in the calcaneus, the feasibility of measuring trabecular bone microstructure is explored. The combination of R2* for measuring intra-voxel dephasing and quantitative magnetic susceptibilty to detect trabecular bone density is investigated and indicates feasibility to differentiate trabecular bone networks with isotropic and anisotropic microstructure.

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