Abstract #0536

Repeatability and Reproducibility of a New Method for Quantifying Triglyceride Saturation Using Bipolar Multi-Echo MRI

Manuel Schneider¹, Felix Lugauer¹, Gemini Janas^2,3, Dominik Nickel⁴, Brian M Dale⁵, Berthold Kiefer⁴, Andreas Maier¹, and Mustafa R Bashir^2,3

¹Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, ²Radiology, Duke University Medical Center, Durham, NC, United States, ³Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, ⁴MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, ⁵MR R&D Collaborations, Siemens Healthineers, Cary, NC, United States

Our purpose was to develop a robust method for joint quantification of water and fat fractions as well as fatty acid maps from bipolar multi-echo MR data. Its accuracy and reproducibility across field strengths and sequences was demonstrated using an oil phantom. Repeated in-vivo breath-hold acquisitions in n = 11 patients yielded median absolute differences of 4.8%, 1.0% and 8.2% for the saturated, mono-unsaturated and poly-unsaturated fat components in the liver, spleen and subcutaneous, perirenal and mesenteric fat depots.

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