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Abstract #0536

Repeatability and Reproducibility of a New Method for Quantifying Triglyceride Saturation Using Bipolar Multi-Echo MRI

Manuel Schneider1, Felix Lugauer1, Gemini Janas2,3, Dominik Nickel4, Brian M Dale5, Berthold Kiefer4, Andreas Maier1, and Mustafa R Bashir2,3

1Pattern Recognition Lab, Department of Computer Science, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany, 2Radiology, Duke University Medical Center, Durham, NC, United States, 3Center for Advanced Magnetic Resonance Development, Duke University Medical Center, Durham, NC, United States, 4MR Application Predevelopment, Siemens Healthcare GmbH, Erlangen, Germany, 5MR R&D Collaborations, Siemens Healthineers, Cary, NC, United States

Our purpose was to develop a robust method for joint quantification of water and fat fractions as well as fatty acid maps from bipolar multi-echo MR data. Its accuracy and reproducibility across field strengths and sequences was demonstrated using an oil phantom. Repeated in-vivo breath-hold acquisitions in n = 11 patients yielded median absolute differences of 4.8%, 1.0% and 8.2% for the saturated, mono-unsaturated and poly-unsaturated fat components in the liver, spleen and subcutaneous, perirenal and mesenteric fat depots.

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