Meeting Banner
Abstract #0566

MR Imaging Biomarkers of Cardiac Function and Rotational Mechanics in Boys with Duchenne Muscular Dystrophy

Patrick Magrath1, Pierangelo Renella2, Nancy Halnon3, Subha Raman4,5, and Daniel B. Ennis1,2

1Department of Bioengineering, University of California, Los Angeles, CA, United States, 2Department of Radiology, University of California, Los Angeles, CA, United States, 3Department of Medicine (Cardiology), University of California, Los Angeles, CA, United States, 4Department of Internal Medicine/Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, United States, 5Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, United States

Duchenne Muscular Dystrophy (DMD) severely impacts heart health. Decreasing LV ejection fraction (EF) is a late and highly variable outcome in this cohort. Earlier indications of cardiac involvement would improve patient management and provide insight into the utility of emerging therapy. Boys with DMD (N=25) and healthy volunteers (N=8) underwent cardiac MRI exams including short-axis tagged images. EF, peak LV twist, and peak mid-wall circumferential strain (Ecc) were estimated. Ecc and twist were significantly reduced in patients (9.3°±4.3° vs. 14.8°±3.6°, p< 0.004) and (-15.8±5.8% vs. -18.5±3.2%, p<0.02). Whereas, EF was not significantly different between groups. ~50% of DMD patients with normal EF had reduced twist and Ecc. Reduced peak LV twist and mid-wall Ecc measured by MR tagging may be earlier and more sensitive indicators of cardiac involvement in boys with DMD.

This abstract and the presentation materials are available to members only; a login is required.

Join Here

Abstract