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Abstract #0582

Contrast-enhanced MR microscopy of amyloid plaques in five mouse models of Alzheimer’s disease: comparison with amyloid plaques detection in human brains.

Clémence Dudeffant 1, Matthias Vandesquille1, Kelly Herbert1, Sandro Alves2, Emmanuel Comoy3, Fanny Petit1, and Marc Dhenain1

1Molecular Imaging Research Center (MIRCen), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fontenay aux Roses, France, 2INSERM U986, Université Paris-Sud, Fontenay-aux-Roses, France, 3Institut des Maladies Emergentes et des Therapies Innovantes (IMETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Fontenay aux Roses, France

Gadolinium(Gd)-stained MRI is based on Gd-contrast agent administration into the brain. This method significantly improves the detection of amyloid plaques, one of the lesions of Alzheimer's disease and a potential biomarker for its diagnosis. Here, we aimed to better understand the origin of contrast induced by amyloid plaques by determining critical parameters required for their detection using five mouse models of amyloidosis presenting with different plaque typologies. Then, we showed for the first time that Gd-stained MRI can detect amyloid plaques in postmortem human brain tissues and compared the detection achieved in mice with those obtained in human samples.

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