Abstract #0590

Resting-state functional connectivity alterations in adolescents with fetal alcohol spectrum disorders

Jia Fan^1,2, Joseph L. Jacobson^2,3,4, Christopher D. Molteno⁴, Sandra W. Jacobson^2,3,4, and Ernesta M. Meintjes^1,2

¹MRC/UCT Medical Imaging Research Unit, Division of Biomedical Engineering, University of Cape Town, Cape Town, South Africa, ²Department of Human Biology, University of Cape Town, Cape Town, South Africa, ³Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, ⁴Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa

In a study of children with fetal alcohol spectrum disorders (FASD) and community controls assessed at age 11 years, alcohol-exposed children showed localised dose-dependent reductions in resting state functional connectivity (FC) in 5 gray matter regions within 5 resting state networks. Here we present data from a follow-up study of these children at age 15 years to examine whether these FC deficits persist or resolve.

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