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Abstract #0592

Integrated structural and functional connectivity analysis to characterize abnormalities in ADHD

Lipeng Ning1,2, Sarina Karmacharya1, Hesham Hamoda3, Gloria McAnulty3, Deborah Waber3, and Yogesh Rathi1,2

1Brigham and Women's Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Boston Children's Hospital, Boston, MA, United States

We introduce a novel approach for integrating novel diffusion MRI (dMRI) derived microstructural properties and resting state functional MRI (rsfMRI) derived functional measures to obtain a comprehensive understanding of brain abnormalities in neuropsychiatric disorders. We applied this methodology to study abnormalities in children with attention-deficit hyperactivity disorder (ADHD), providing a probabilistic view of the abnormal connections, thus accounting for the heterogeneity in the presentation of ADHD. We further show that the integrated analysis is significantly more sensitive than separate dMRI and rsfMRI analyses. Apart from known connections reported to be abnormal in the literature, we find several new abnormal connections in ADHD subjects with high probability.

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