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Abstract #0652

MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum

Yi Chen1,2, Pais Roldán Patricia1,2, Xuming Chen1, and Xin Yu1,3

1Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, 3The Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany

An MRI-compatible robotic arm was developed to provide a precise fiber positioning for optogenetic fMRI of the rat brain. Corpus callosum connects two hemispheres through a thin sheet of spreading fiber bundle with only a few hundred micron thickness in the brain. This work shows that MgRA can guide fiber optic to precisely target the callosal fiber bundles. The optogenetically driven callosal axonal fiber-mediated neural activity leads to strong antidromic activation in the hemisphere with callosal neurons expressing ChR2 by fMRI.

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