Abstract #0652

MRI-guided robotic arm (MgRA) drives optogenetic activation of the rat corpus callosum

Yi Chen^1,2, Pais Roldán Patricia^1,2, Xuming Chen¹, and Xin Yu^1,3

¹Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²Graduate Training Centre of Neuroscience, University of Tuebingen, Tuebingen, Germany, ³The Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany

An MRI-compatible robotic arm was developed to provide a precise fiber positioning for optogenetic fMRI of the rat brain. Corpus callosum connects two hemispheres through a thin sheet of spreading fiber bundle with only a few hundred micron thickness in the brain. This work shows that MgRA can guide fiber optic to precisely target the callosal fiber bundles. The optogenetically driven callosal axonal fiber-mediated neural activity leads to strong antidromic activation in the hemisphere with callosal neurons expressing ChR2 by fMRI.

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