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Abstract #0671

Comparison of cervical cord results from a quantitative 3D multi-parameter mapping (MPM) protocol of the whole brain with a dedicated cervical cord protocol

Rebecca Sara Samson1, Marco Battiston1, Maryam Seif2,3, Julien Cohen-Adad4,5, Patrick Freund2,3,6, and Claudia Angela Gandini Wheeler-Kingshott1,7,8

1Queen Square MS Centre, University College London, London, United Kingdom, 2Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, 3Neurophysics Department, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 4NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 5Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, 6Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, 7Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, 8Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy

We present a comparison of cervical cord metrics obtained using both a whole brain and dedicated cord implementation of a recently introduced quantitative multi-parametric MRI protocol which provides apparent proton density, R1, magnetisation transfer saturation (MTsat) and R2* maps sensitive to microstructural tissue changes in brain and spinal cord. Similar whole cervical cord (levels C1-C5) parameters were obtained using either protocol, and inter-subject variation was low, however in order to investigate tissue-specific cord parameters the dedicated cord protocol with higher in-plane resolution would be desirable.

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