Abstract #0671

Comparison of cervical cord results from a quantitative 3D multi-parameter mapping (MPM) protocol of the whole brain with a dedicated cervical cord protocol

Rebecca Sara Samson¹, Marco Battiston¹, Maryam Seif^2,3, Julien Cohen-Adad^4,5, Patrick Freund^2,3,6, and Claudia Angela Gandini Wheeler-Kingshott^1,7,8

¹Queen Square MS Centre, University College London, London, United Kingdom, ²Spinal Cord Injury Center Balgrist, University of Zurich, Zurich, Switzerland, ³Neurophysics Department, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁴NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada, ⁵Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada, ⁶Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom, ⁷Department of Brain and Behavioural Sciences, University of Pavia, Pavia, Italy, ⁸Brain MRI 3T Centre, C. Mondino National Neurological Institute, Pavia, Italy

We present a comparison of cervical cord metrics obtained using both a whole brain and dedicated cord implementation of a recently introduced quantitative multi-parametric MRI protocol which provides apparent proton density, R₁, magnetisation transfer saturation (MT_sat) and R₂* maps sensitive to microstructural tissue changes in brain and spinal cord. Similar whole cervical cord (levels C1-C5) parameters were obtained using either protocol, and inter-subject variation was low, however in order to investigate tissue-specific cord parameters the dedicated cord protocol with higher in-plane resolution would be desirable.

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