Abstract #0674

Optimal Experiment Design for Magnetic Resonance Fingerprinting: New Insights and Further Improvements

Bo Zhao^1,2, Justin P. Haldar³, Congyu Liao¹, Dan Ma⁴, Mark A. Griswold⁴, Kawin Setsompop^1,2, and Lawrence L. Wald^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Chalestown, MA, United States, ²Harvard Medical School, Boston, MA, United States, ³Electrical Engineering, University of Southern California, Los Angeles, CA, United States, ⁴Radiology, Case Western Reserve University, Cleveland, OH, United States

The Cramer-Rao bound (CRB) based experiment design was previously described to optimize the SNR efficiency of MRF experiments. Here we revisit such a problem and provide new insights. Specifically, we present a new CRB-based experiment design approach, which introduces an additional set of constraints on the variation of flip angles to enforce the smoothness of the magnetization evolution. We demonstrate that the proposed approach is advantageous for highly-undersampled MRF experiments. We evaluated the effectiveness of the proposed approach with both simulations and phantom experiments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.