Abstract #0701

High resolution T1-weighted brain imaging and segmentation at 7T: a travelling head study

Olivier E. Mougin¹, William T Clarke², Ian Driver³, Catarina Rua⁴, Adrian Carpenter⁴, Susan Francis¹, Keith Muir⁵, Richard Wise³, Stuart Clare², and Richard Bowtell¹

¹School of Physics and Astronomy, University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, ²Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford, United Kingdom, ³School of Psychology, Cardiff University, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, ⁴Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, ⁵University of Glasgow, Institute of Neuroscience & Psychology, Glasgow, United Kingdom

Ultra-high magnetic field (7T) MRI scanners can provide high spatial resolution images and excellent contrast for classifying brain tissue in vivo, but imaging reproducibility and tissue segmentation between sites is key for multi-site studies. Here, we present a travelling-head study focusing on the harmonized acquisition and segmentation of T₁-weighted images acquired on three subjects at 0.7mm³ isotropic resolution at four different 7T sites. The aim of the study is to assess the harmonisation and robustness of the MPRAGE and MP₂RAGE sequence across sites, by focusing on segmentation reproducibility and T₁ estimation.

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