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Abstract #0701

High resolution T1-weighted brain imaging and segmentation at 7T: a travelling head study

Olivier E. Mougin1, William T Clarke2, Ian Driver3, Catarina Rua4, Adrian Carpenter4, Susan Francis1, Keith Muir5, Richard Wise3, Stuart Clare2, and Richard Bowtell1

1School of Physics and Astronomy, University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom, 2Nuffield Department of Clinical Neurosciences, University of Oxford, Wellcome Centre for Integrative Neuroimaging (FMRIB), Oxford, United Kingdom, 3School of Psychology, Cardiff University, Cardiff University Brain Research Imaging Centre, Cardiff, United Kingdom, 4Department of Clinical Neurosciences, University of Cambridge, Wolfson Brain Imaging Centre, Cambridge, United Kingdom, 5University of Glasgow, Institute of Neuroscience & Psychology, Glasgow, United Kingdom

Ultra-high magnetic field (7T) MRI scanners can provide high spatial resolution images and excellent contrast for classifying brain tissue in vivo, but imaging reproducibility and tissue segmentation between sites is key for multi-site studies. Here, we present a travelling-head study focusing on the harmonized acquisition and segmentation of T­1-weighted images acquired on three subjects at 0.7mm3 isotropic resolution at four different 7T sites. The aim of the study is to assess the harmonisation and robustness of the MPRAGE and MP2RAGE sequence across sites, by focusing on segmentation reproducibility and T­1 estimation.

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