Abstract #0731

Development of advanced multiparametric MRI biomarkers of Alzheimer’s disease

Ashley M. Stokes¹, Zhiqiang Li², James G. Pipe², Richard J. Caselli³, Marwan N. Sabbagh⁴, and Leslie C. Baxter⁵

¹Translational Bioimaging Group, Barrow Neurological Institute, Phoenix, AZ, United States, ²Magnetic Resonance Technology Design Group, Barrow Neurological Institute, Phoenix, AZ, United States, ³Mayo Clinic - Arizona, Scottsdale, AZ, United States, ⁴Neurology, Alzheimer’s and Memory Disorders, Barrow Neurological Institute, Phoenix, AZ, United States, ⁵Human Brain Mapping Laboratory, Barrow Neurological Institute, Phoenix, AZ, United States

The goal of this project is to establish advanced MRI signatures of each stage of Alzheimer’s disease (AD), including preclinical, mild cognitive impairment (MCI), and dementia stages. These advanced imaging methods will allow us to non-invasively investigate the underlying neurobiological changes that precede cognitive impairment. While structural MRI is known to change with disease progression, advanced MR imaging may provide more specific signatures of disease progression. The asymptomatic and MCI phases represent a clear potential for early intervention, and the non-invasive methods developed here may identify patients along the clinical trajectory of AD.

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