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Abstract #0748

Quantifying diameter overestimation of undulating axons from synthetic DW-MRI

Alonso Ramirez-Manzanares1, Mario Ocampo-Pineda2, Jonathan Rafael-Patiño3, Giorgio Innocenti3,4,5, Jean-Philippe Thiran3, and Alessandro Daducci2,3,6

1Computer Science, Centro de Investigación en Matemáticas A.C., Guanajuato, Mexico, 2University of Verona, Verona, Italy, 3Signal Processing Lab (LTS5), École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 4Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, 5Brain and Mind Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, 6University Hospital Center (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

This study aims to provide to the research community quantitative measurements about the axon diameter overestimation due to the straight-cylinder assumption usually made in state-of-the-art models for diameter mapping with DW-MRI. Our methodology uses a Monte Carlo diffusion simulator to compute the diffusion weighted magnetic resonance signals of undulating axons. We use in our experiments plausible tissue values, we also explore a broad parameter set that depicts undulation. The results of this study provide useful information to understand the differences between the estimators from histology vs. the estimated diameters when using the model assumption of simple shaped axons.

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