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Abstract #0755

Rapid Single Shot Whole Lung Acquisition of for Hyperpolarized Gas MRI Biomarkers of Airspace Enlargement.

Alexei Ouriadov1,2, Dante PI Capaldi1,2, David McCormack3, and Grace Parraga1,2,3

1Robarts Research Institute, London, ON, Canada, 2Department of Medical Biophysics, Western University, London, ON, Canada, 3Division of Respirology, Department of Medicine, Western University, London, ON, Canada

Hyperpolarized gas pulmonary MRI provides physiologically relevant biomarkers of obstructive lung disease including emphysema, bronchopulmonary dysplasia, congenital lobar emphysema and alpha-1 antitrypsin deficiency. Recently, a stretched-exponential-model combined with under-sampling in the imaging and diffusion directions was proposed for the evaluation of hyperpolarized gas multiple b-value diffusion-weighted MRI. The major advantage of this method is the possibility to significantly speed up the data acquisition using acceleration factors between 7 and 10. We hypothesize that this method can be extended to provide whole lung hyperpolarized gas MRI-based emphysema biomarkers including static-ventilation, T2* ADC and morphometry maps with high spatial image resolution.

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