Abstract #0794

Assessment of the total iron mass using Quantitative Susceptibility Mapping (QSM): Deep gray matter iron depletion in multiple sclerosis?

Ferdinand Schweser^1,2, Jesper Hagemeier¹, Michael G Dwyer¹, Niels P Bergsland^1,3, Akshay V Dhamankar¹, Bianca Weinstock-Guttman⁴, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ²Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³MR Research Laboratory, IRCCS, Don Gnocchi Foundation ONLUS, Milan, Italy, ⁴BairdMS Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States

It is often overlooked that iron concentrations, as determined, e.g., via Quantitative Susceptibility Mapping (QSM), reflect the mass of iron per unit volume. Consequently, structural atrophy alone (i.e. decreased volume) increases the tissue iron concentration if the total mass of iron remains constant.

In this work, we present a technique to assess the mass of regional tissue iron in milligrams (mg). We retrospectively applied the technique to data from a recently published 2-year longitudinal study, in which we had investigated iron concentration changes in Multiple Sclerosis (MS).

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