Meeting Banner
Abstract #0804

Parametric Response Mapping of Normalized FLAIR MR Images Provides Early Indication of Recurrence Risk in Glioblastoma

Benjamin A. Hoff1, Craig J. Galbán2, Thomas L. Chenevert2, Gary D. Luker2, Benjamin Lemasson3, Timothy D. Johnson4, and Brian D. Ross2

1University of Michigan, Ann Arbor, MI, United States, 2Radiology, University of Michigan, Ann Arbor, MI, United States, 3Grenoble Institut des Neurosciences, GIN, Universite Grenoble Alpes, Grenoble, France, 4Biostatistics, University of Michigan, Ann Arbor, MI, United States

Glioblastoma is a particularly malevolent disease, with median expected survival around 14 months. Standard protocols for treatment assessment and recurrence rely on morphological approximations of tumor burden. Recently included by the RANO criteria, T2/FLAIR is now standard in imaging protocols, highlighting edema, presumed to be associated with tumor cell infiltration and critical for accurate description of tumor burden and radiation treatment planning. Advanced methods for early detection of change are underutilized. Application of the Parametric Response Map technique provides greater sensitivity to FLAIR signal changes indicative of tumor progression prior to those detectable by morphological analysis alone.

This abstract and the presentation materials are available to members only; a login is required.

Join Here