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Abstract #0817

Increased T1Rho relaxation in a Duchenne muscular dystrophy mouse model with increased muscle fibrosis

Bauke Kogelman1, Kevin Adamzek2, Ernst Suidgeest1, Gustav Strijkers3, Maaike van Putten2, and Louise van der Weerd1,2

1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Human Genetics, Leiden University Medical Center, Leiden, Netherlands, 3Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands

A T1Rho sequence was used in a Duchenne Muscular Dystrophy mouse model characterized by increased muscle fibrosis. Significantly higher T1Rho relaxation times were found compared to wild-type mice in which fibrosis was absent. Although both T1Rho and T2 values were increased, the increase was more pronounced for T1Rho than for T2 (14.2% vs 3.6%), indicating that T1Rho is affected by other processes than those resulting in increased T2 values. These data demonstrate the potential of T1Rho to assess muscle fibrosis in vivo.

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