Abstract #0817

Increased T1Rho relaxation in a Duchenne muscular dystrophy mouse model with increased muscle fibrosis

Bauke Kogelman¹, Kevin Adamzek², Ernst Suidgeest¹, Gustav Strijkers³, Maaike van Putten², and Louise van der Weerd^1,2

¹Radiology, Leiden University Medical Center, Leiden, Netherlands, ²Human Genetics, Leiden University Medical Center, Leiden, Netherlands, ³Preclinical and Translational MRI, Academic Medical Center, Amsterdam, Netherlands

A T1Rho sequence was used in a Duchenne Muscular Dystrophy mouse model characterized by increased muscle fibrosis. Significantly higher T1Rho relaxation times were found compared to wild-type mice in which fibrosis was absent. Although both T1Rho and T2 values were increased, the increase was more pronounced for T1Rho than for T2 (14.2% vs 3.6%), indicating that T1Rho is affected by other processes than those resulting in increased T2 values. These data demonstrate the potential of T1Rho to assess muscle fibrosis in vivo.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.