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Abstract #0827

Pancreas perfusion and transit-time measurement using pseudo-continuous ASL

Manuel Taso1, Arnaud Guidon2, Li Zhao1, Koenraad J. Mortele1, and David C. Alsop1

1Division of MRI Research, department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States, 2Global MR Applications and Workflow, GE Healthcare, Boston, MA, United States

While there are strong interests in non-contrast pancreatic perfusion measurement, reports of ASL use for this purpose are rare due to several challenges. In this work, we investigate the robustness of background-suppressed-pCASL for pancreatic perfusion, with an emphasis on quantifying blood-flow (PBF) and transit-time (ATT) using multiple-delays ASL. Robust ASL signal was obtained in all volunteers, and ATT was measured to be 1029±89ms. Measured ATT-corrected PBF was 162±12mL/100g.min. Evidence of heterogeneity in ATT and PBF was found, potentially linked to the complex vascular supply and different exocrine/endocrine functions. Hence, pCASL PBF measurement is feasible and holds promise for clinical studies.

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